First the Astros move to the AL which will happen in a couple years.
Second. You would play eight 3 games series' against your division teams totaling 96 games. The MLB season is 6 months long from April through September. You would play 3 in April, 4 in May, 5 in June, 5 in July, 7 in August, and 8 in September.
Third. Each team would play the other 10 teams in their league in two 3 games series' totaling 60 games. This games would be toward the beginning of the season and would be more limited towards the end. Each series would be a home and home.
Fourth. Each team would have one designated opposite league team that they would play a home and home with during the season. These two series would come just before the All-Star break and just after.
Here are the team match-ups.
A's vs. Giants
Astros vs. Rockies
This schedule would put more importance on playing well at the end of the season.